The Christian destruction of pagan wisdom is attested in
this time line, extracted from Demolish Them! by Vlassis R. Rassias.
I suspect some of its claims would be contested by apologists, but the general drift is clear and inexorable, and incompatible with claims that Christendom was compatible with reason.
On the Euphrates running black, that is a reference to the Arab destruction of Persian libraries in the first millennium. This process was well underway under Christendom, as per Chrysostom's mention of throwing books in rivers.
Extracts from Pagan Destruction Chronology
Source: Demolish Them! Vlassis R. Rassias
314 Immediately after its full legalization, the Christian Church attacks the gentiles (non-Christians). The Council of Ancyra denounces the worship of Goddess Artemis.
324 The emperor Constantine declares Christianity as the only official religion of the Roman empire. In Dydima, Minor Asia, he sacks the Oracle of the god Apollo and tortures the pagan priests to death. He also evicts all non-Christian peoples from Mount Athos and destroys all the local Hellenic temples.
335 Constantine orders the execution by crucifixion of "all magicians and soothsayers."
346 New large scale persecutions against non-Christian peoples in Constantinople.
354 A new edict orders the closing of all the pagan temples. First burning of libraries in various cities of the empire.
359 In Skythopolis, Syria, the Christians organize the first death camps for the torture and executions of the arrested non-Christians from all around the empire.
361 to 363 Religious tolerance and restoration of the pagan cults declared in Constantinople (11th December 361) by the pagan emperor Flavius Claudius Julianus.
364 Emperor Flavius Jovianus orders the burning of the Library of Antioch. An Imperial edict (11th September) orders the death penalty for all those that worship their ancestral gods
370 Valens orders a tremendous persecution of non-Christian peoples in all the Eastern Empire. Tons of books are burnt in the squares of the cities of the Eastern Empire.
372 Valens orders the governor of Minor Asia to exterminate all the Hellenes and all documents of their wisdom.
373 New prohibition of all divination methods. The term "pagan" (pagani, villagers, equivalent to the modern insult, "peasants") is introduced by the Christians to demean non-believers.
375 The temple of god Asclepius in Epidaurus, Greece, is closed down by the Christians.
380 On 27th February, Christianism becomes the exclusive religion of the Roman empire by an edict of the emperor Flavius Theodosius, requiring that:
All the various nations which are subject to our clemency and moderation should continue in the profession of that religion which was delivered to the Romans by the divine Apostle Peter. The non-Christians are called "loathsome, heretics, stupid and blind". In another edict, Theodosius calls "insane" those that do not believe to the Christian God and outlaws all disagreements with the Church dogmas. Ambrosius, bishop of Milan, starts destroying all the pagan temples of his area. The Christian priests lead the hungry mob against the temple of goddess Demeter in Eleusis and try to lynch the hierophants Nestorius and Priskus. The 95 years old hierophant Nestorius ends the Eleusinian Mysteries and announces the predominance of mental darkness over the human race.
381 On 2nd May, Theodosius deprives of all their rights the Christians that return back to the pagan religion. In all the Eastern Empire the pagan temples and Libraries are looted or burned down.
385 to 388 Maternus Cynegius, encouraged by his fanatic wife, and bishop "Saint" Marcellus with his gangs scour the countryside and sack and destroy hundreds of Hellenic temples, shrines and altars. Among others they destroy the temple of Edessa, the Cabeireion of Imbros, the temple of Zeus in Apamea, the temple of Apollo in Dydima and all the temples of Palmyra. Thousands of innocent pagans from all sides of the empire suffer martyrdom in the notorious death camps of Skythopolis.
388 Public talks on religious subjects are outlawed by Theodosius.
389 to 390 All non-Christian date-methods are outlawed. Hordes of fanatic hermits from the desert flood the cities of the Middle East and Egypt and destroy statues, altars, libraries and pagan temples, and lynch the pagans. Theophilus, Patriarch of Alexandria, starts heavy persecutions against non-Christian peoples, turns the temple of Dionysos into a Christian church, burns down the Mithraeum of the city, destroys the temple of Zeus and burlesques the pagan priests before they are killed by stoning. The Christian mob profanes the cult images.
391 On 24th February, a new edict of Theodosius prohibits not only visits to pagan temples but also looking at the vandalized statues. New heavy persecutions all around the empire. In Alexandria, Egypt, pagans, led by the philosopher Olympius, revolt and after some street fights they lock themselves inside the fortified temple of god Serapis (the Serapeion). After a violent siege, the Christians take over the building, demolish it, burn its famous library and profane the cult images.
396 edict by Arcadius orders that paganism be treated as high treason.
398 The Fourth Church Council of Carthage prohibits to everybody, including to the Christian bishops, the study of the books of the pagans.
405 John Chrysostom sends hordes of gray dressed monks armed with clubs and iron bars to destroy the "idols" in all the cities of Palestine.
408 Private ownership of pagan sculpture is outlawed. New heavy persecutions against the pagans and new book burning. The judges that have pity for the pagans are also persecuted. "Saint" Augustine massacres hundreds of protesting pagans in Calama, Algeria.
409 Edict orders all methods of divination to be punished by death.
435 death penalty for all "heretics" and pagans
448 Theodosius II orders all non-Christian books to be burned.
450 All the temples of Aphrodisias (the City of the Goddess Aphrodite) are demolished and all its libraries burned down. The city is renamed Stavroupolis (City of the Cross).
528 Justinian orders the execution—by fire, crucifixion, tearing to pieces by wild beasts or cutting to pieces by iron nails—of all who practice "sorcery, divination, magic or idolatry" and prohibits all teachings by the pagans ("the ones suffering from the blasphemous insanity of the Hellenes").
529 Justinianus outlaws the Athenian Philosophical Academy and has its property confiscated.
556 Justinianus orders the notorious inquisitor Amantius to go to Antioch, to find, arrest, torture and exterminate the last non-Christians of the city and burn all the private libraries down.